Quinolines and derivatives

Aromatic organic heterocyclic compounds that contain a benzene ring fused with a six-membered ring that contains one nitrogen atom and five carbon atoms. Includes compounds that are derived from quinolines.

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2,341 – 2,355 of 5,527 results

2,341

Ambeed 1R 2S 1Amino2 3dihydro1Hinden

(1R,2S)-1-Amino-2,3-dihydro-1H-inden-2-ol, 136030-00-7, 98%

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2,342

Apexbio Technology LLC Amsacrine 51264-14-3 200mg

Amsacrine (CAS 51264-14-3) also known as m-AMSA is a small-molecule inhibitor of DNA topoisomerase II It is widely used as an antineoplastic agent in biomedical research particularly for investigating the treatment of lymphomas and acute leukemias Amsacrine exhibits cytotoxic effects across various cancer cell lines with reported IC50 values of 190 2 27 4 ng/ml 46 1 3 9 ng/ml and 22 6 3 1 ng/ml in HT1376 RT112 and RT4 bladder cancer cells and 11 8 2 0 ng/ml 5 0 0 4 ng/ml and 11 7 1 5 ng/ml in the 833K Susa and GH testicular cancer cell lines respectively Testicular cancer cell lines display greater sensitivity to Amsacrine-induced inhibition than bladder cancer cell lines This compound is valuable for studying DNA damage mechanisms and the cellular response to topoisomerase II inhibition

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2,343

TARGETMOL CHEMICALS INC VU0155069 5MG

Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. VU0155069 strongly inhibits the invasive migration of several cancer cell lines in transwell assays. VU0155069 is a selective phospholipase D1 inhibitor (IC50 46 nM in vitro). purity: 98%

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2,344

TARGETMOL CHEMICALS INC GSK2593074A 5MG

Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. GSK2593074A (GSK'074) is a programmed necrosis inhibitor that displays inhibitory effects on RIP1 and RIP3. purity: 100%

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2,345

eMolecules 68181-17-9 | SPDP | Target Molecule | MFCD00009636 | 312.360 | C12H12N2O4S2 | 0.000 | O=C(CCSSc1ccccn1)ON1C(=O)CCC1=O | 200mg | 348530991

SPDP | Target Molecule | 68181-17-9 | MFCD00009636 | 312.360 | C12H12N2O4S2 | 0.000 | O=C(CCSSc1ccccn1)ON1C(=O)CCC1=O | 200mg | 348530991

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2,346

TARGETMOL CHEMICALS INC YKL-06-061 10MG

Also available in 1 mg 5 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. YKL-06-061 is a selective salt-inducible kinase (SIK) inhibitor with IC50 values of 6.56 nM/1.77 nM/20.5 nM for SIK1/2/3 respectively. purity: 99%

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2,347

Apexbio Technology LLC LDE225 (NVP-LDE225,Erismodegib) 956697-53-3 200mg

LDE225 (NVP-LDE225 Erismodegib CAS 956697-53-3) is a small molecule antagonist of the Smoothened (Smo) receptor a central component in the Hedgehog (Hh) signaling pathway implicated in oncogenic processes Identified through cell-based high-throughput screening of combinatorial libraries LDE225 demonstrates potent inhibition of Smo with IC50 values of 1 3 nM in murine models and 2 5 nM in human systems Preclinical studies showed marked suppression of tumor growth in medulloblastoma xenograft mouse models following oral administration with evidence of blood-brain barrier permeability LDE225 is widely used for investigating Hh pathway modulation and its role in cancer research

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2,348

Medchemexpress LLC CX516 | 154235-83-3 | 99.94% | 241.29 | 100 MG

CX516 (BDP 12) is an ampakine that functions as an AMPA receptor positive allosteric modulator. It is used in the research of Alzheimer's disease, schizophrenia, and mild cognitive impairment (MCI).

Acts as an AMPA receptor positive allosteric modulator.
Used in research for Alzheimer's disease, schizophrenia, and mild cognitive impairment (MCI).

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2,349

Apexbio Technology LLC Nootkatone 4674-50-4 200mg

Nootkatone (CAS nan) is a naturally derived agent investigated for its neuroprotective effects It is designed to modulate intracellular signaling pathways and enzymatic activities associated with neuroinflammation and oxidative stress thereby regulating neuronal cellular processes Nootkatone exerts its biological activity primarily through modulation of signaling pathways and enzymatic activities linked to neuroinflammation and oxidative stress In animal models specifically lipopolysaccharide (LPS)-induced Alzheimer s disease in mice Nootkatone demonstrates amelioration of cognitive impairment Based on these pharmacological properties Nootkatone holds research potential in neuronal protection cognitive function restoration and elucidation of mechanisms related to neurodegenerative pathology

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2,350

Medchemexpress LLC Dabigatran etexilate (mesylate) | 872728-81-9 | MFCD25424070 | 99.8% | 723.8 g·mol⁻¹ | C35H45N7O8S | 200 MG

Dabigatran etexilate mesylate is the mesylate salt of dabigatran etexilate, an orally active prodrug of the direct thrombin inhibitor dabigatran. It is supplied as a solid for research use and is characterized by high purity and analytical documentation.

Oral prodrug of dabigatran, a direct thrombin inhibitor.
Used in research for anticoagulant and antithrombotic studies.
Provided as the mesylate salt in solid form suitable for analytical and formulation work.
High reported purity (≈99.8%) with accompanying certificate of analysis.
Molecular weight 723.8 g·mol⁻¹ and chemical formula C35H45N7O8S.
Identified by CAS number 872728-81-9 for unambiguous substance reference.

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2,351

Medchemexpress LLC 5-amino-6-chloro-n-[(1-isobutylpiperidin-4-yl)methyl]-2-methylimidazo[1,2-a]pyridine-8-carboxamide | 519148-48-2 | 98.3% | 377.91 g/mol | C19H28ClN5O | 200 MG

CJ033466 is a research-grade selective 5-HT4 receptor partial agonist with a reported EC50 of 9 nM and demonstrated gastroprokinetic activity. It is supplied as a purified solid intended for in vitro and in vivo pharmacology research.

Selective 5-HT4 receptor partial agonist (EC50 9 nM).
Reported gastroprokinetic activity in preclinical studies.
High purity (98.29%), suitable for pharmacology research.
Molecular formula C19H28ClN5O; molecular weight 377.91 g/mol.
Soluble in DMSO (50 mg/mL) with ultrasonic/warming up to 80°C.
Storage: solid at 4°C; in solvent -80°C (6 months), -20°C (1 month).
Available in research quantities including 200 mg.

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2,352

Medchemexpress LLC Daclatasvir | 1009119-64-5 | MFCD18074519 | 98.7% | 738.88 g/mol | C40H50N8O6 | 200 MG

Daclatasvir is a potent NS5A inhibitor used as a research reagent to study hepatitis C virus replication and related pharmacology. The compound shows picomolar-range antiviral activity across multiple HCV genotypes and also inhibits OATP1B and OATP1B3 transporters. It is supplied as a high-purity solid and is commonly provided in solution formats for in vitro assays.

Potent NS5A inhibition with EC50s in the picomolar range.
High purity suitable for biochemical and cellular assays.
Available in multiple pack sizes for small- and large-scale experiments.
Soluble in DMSO and commonly supplied as 10 mM solution for convenience.
Also inhibits OATP1B and OATP1B3, relevant for transporter studies.
Molecular weight 738.88 g/mol for formula-based calculations.

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2,353

Apexbio Technology LLC Indoximod (NLG-8189) 110117-83-4 200mg

Indoximod (NLG-8189 CAS 110117-83-4) is an orally bioavailable small molecule that targets the indoleamine 2 3-dioxygenase (IDO) pathway a key regulator of tryptophan metabolism involved in tumor-mediated immune suppression By blocking IDO activity indoximod reduces the expansion of regulatory T cells (Tregs Foxp3 /CD4 /CD25 ) thereby attenuating tumor-associated immune tolerance Preclinical studies have demonstrated that indoximod enhances adaptive immune responses to antigens and dendritic cell vaccines and its combination with chemotherapeutics such as docetaxel has shown increased toxicity without reaching a maximum tolerated dose at 2000 mg twice daily Indoximod serves as a valuable tool in investigating immunoregulatory mechanisms and immunotherapy strategies in cancer research

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2,354

TARGETMOL CHEMICALS INC PROCAINAMIDE 50MG

Also available in 100 mg 200 mg 500 mg and bulk. Please contact Fisher for quotes. Procainamide (Novocainamide) is a specific and potent DNA methyltransferase 1 ( DNMT1 ) inhibitor. Procainamide is a Class 1A antiarrhythmic agent. Procainamide has the potential for the research of cancer and arrhythmias [1] [2]. purity: 98%

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2,355

Apexbio Technology LLC SM-164 957135-43-2 200mg

SM-164 (CAS 957135-43-2) is a bivalent small molecule mimetic of the endogenous inhibitor Smac designed to antagonize cellular inhibitor of apoptosis proteins (cIAP-1 cIAP-2) and X-linked inhibitor of apoptosis protein (XIAP) By binding specifically to the BIR2 and BIR3 domains of cIAP-1 and XIAP as well as the BIR3 domain of cIAP-2 (Ki of 0 31 nM 0 56 nM and 1 1 nM respectively) SM-164 promotes degradation of cIAP-1 and inhibition of XIAP In tumor cells this leads to caspase activation and TNF -dependent apoptosis SM-164 is utilized in cancer research to investigate apoptosis regulation and anticancer therapy strategies

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Quinolines and derivatives

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Medchemexpress LLC CX516 | 154235-83-3 | 99.94% | 241.29 | 100 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Dabigatran etexilate (mesylate) | 872728-81-9 | MFCD25424070 | 99.8% | 723.8 g·mol⁻¹ | C35H45N7O8S | 200 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC 5-amino-6-chloro-n-[(1-isobutylpiperidin-4-yl)methyl]-2-methylimidazo[1,2-a]pyridine-8-carboxamide | 519148-48-2 | 98.3% | 377.91 g/mol | C19H28ClN5O | 200 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Daclatasvir | 1009119-64-5 | MFCD18074519 | 98.7% | 738.88 g/mol | C40H50N8O6 | 200 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC CX516 | 154235-83-3 | 99.94% | 241.29 | 100 MG

Medchemexpress LLC Dabigatran etexilate (mesylate) | 872728-81-9 | MFCD25424070 | 99.8% | 723.8 g·mol⁻¹ | C35H45N7O8S | 200 MG

Medchemexpress LLC 5-amino-6-chloro-n-[(1-isobutylpiperidin-4-yl)methyl]-2-methylimidazo[1,2-a]pyridine-8-carboxamide | 519148-48-2 | 98.3% | 377.91 g/mol | C19H28ClN5O | 200 MG

Medchemexpress LLC Daclatasvir | 1009119-64-5 | MFCD18074519 | 98.7% | 738.88 g/mol | C40H50N8O6 | 200 MG